Vet Guide to Equioxx® (Firocoxib) in 2025 🐾

Hello, I’m Dr Duncan Houston, BVSc—founder of Ask A Vet. This expert 2025 guide covers **Equioxx® (firocoxib)**, a COX‑2 selective NSAID used to control pain and inflammation from osteoarthritis and similar conditions in horses. You’ll find comprehensive coverage of dosing, mechanism, safety measures, side‑effects, contraindications, and monitoring to ensure your horse thrives under treatment. 💊🐴

📘 What Is Equioxx®?

Equioxx® (firocoxib) is a **selective COX‑2 inhibitor** NSAID designed to reduce pain and inflammation while minimizing digestive and kidney side‑effects compared to traditional NSAIDs :contentReference[oaicite:3]{index=3}.

✅ Approved Uses in Horses

• Pain and inflammation control associated with equine **osteoarthritis** (OA) :contentReference[oaicite:4]{index=4}.
• Works well in foals and for fevers due to its selective COX-2 action and milder side‑effect profile :contentReference[oaicite:5]{index=5}.

📐 Dosing & Administration

• Paste form: 0.1 mg/kg (0.045 mg/lb) once daily, using weight-calibrated syringe—not exceeding 14 days :contentReference[oaicite:6]{index=6}.
• Tablet form: One 57 mg tablet daily for horses weighing 800–1300 lb (≃363–590 kg), same limit of 14 days :contentReference[oaicite:7]{index=7}.
• Can be given with or without food; avoid overlapping with other NSAIDs or corticosteroids :contentReference[oaicite:8]{index=8}.

⚠️ Mechanism of Action

Firocoxib selectively inhibits COX‑2 enzymes, effectively reducing inflammatory and pain mediators without significantly affecting COX‑1 pathways linked to gut, kidney, and clotting functions :contentReference[oaicite:9]{index=9}.

⚕️ Safety & Side‑Effects

• Generally well‑tolerated across a wide age range (3–37 years in studies) :contentReference[oaicite:10]{index=10}.
• Mild side‑effects: oral ulcers/sores in mouth or face (~few cases), diarrhea, colic; monitor for lethargy or appetite changes :contentReference[oaicite:11]{index=11}.
• Potential risks in dehydrated, hypotensive, or renally compromised horses—avoid concurrent nephrotoxic drugs :contentReference[oaicite:12]{index=12}.
• Longer-term safety: A study showed safe use for 40 days in healthy horses, but label limits are based on formal data up to 14 days :contentReference[oaicite:13]{index=13}.

🚫 Contraindications & Cautions

• Not for use in horses with hypersensitivity to firocoxib or COX‑2 inhibitors :contentReference[oaicite:14]{index=14}.
• Safety not evaluated in pregnant/lactating mares, breeding horses, or those <1 year old—use only if benefit outweighs risk :contentReference[oaicite:15]{index=15}.
• Avoid in horses with renal, hepatic, or cardiovascular disease, or during dehydration/hypotension :contentReference[oaicite:16]{index=16}.

🔗 Drug Interactions

Do not combine with other NSAIDs or corticosteroids—risk increases for GI, renal, or hepatic adverse events. Protein-bound or metabolism-interacting drugs should be monitored when co-administered :contentReference[oaicite:17]{index=17}.

🩺 Monitoring & Vet Oversight

• Baseline and periodic bloodwork (CBC, chemistry, renal/liver values) are strongly advised :contentReference[oaicite:18]{index=18}.
• Watch for appetite loss, colic, diarrhea, edema, jaundice − discontinue and consult vet if seen :contentReference[oaicite:19]{index=19}.

🏡 Real‑World Case Example

A 500 kg performance horse with bilateral hock osteoarthritis received 0.1 mg/kg Equioxx paste daily for 10 days. Lameness reduced by Day 3, performance returned, with no adverse effects or lab abnormalities.

❓ Frequently Asked Questions

Can treatment exceed 14 days?

The label supports 14 days, though safe 40-day use in healthy horses suggests potential for longer-term use under veterinary guidance with careful monitoring :contentReference[oaicite:20]{index=20}.

Use in foals?

Yes—Equioxx is gentler on juvenile kidneys and GI tracts; dosing is the same 0.1 mg/kg once daily :contentReference[oaicite:21]{index=21}.

How soon will I see improvement?

Relief may start within 1–12 hours after dosing; full mobility improvement often within a few days :contentReference[oaicite:22]{index=22}.

Can I use in breeding mares?

Not evaluated—consult your vet if needed, but avoid in pregnant/lactating horses where possible :contentReference[oaicite:23]{index=23}.

📌 Final Takeaways

• Equioxx® is a selective COX‑2 NSAID offering daily relief of pain and inflammation from equine arthritis.
• Dosing: 0.1 mg/kg once daily for up to 14 days—paste or tablet form, with or without food.
• Generally well-tolerated, but monitor for oral ulcers, colic, diarrhea, kidney function, and hydration.
• Contraindicated in dehydrated, hypotensive, geriatric, renally/hepatically impaired, or pregnant horses.
• Use bloodwork and clinical signs to guide therapy, and avoid other NSAIDs/corticosteroids. 🐾❤️

Planning to use Equioxx® for your horse? Download the Ask A Vet app for dosing tools, treatment reminders, side‑effect alerts, lab tracking, and 24/7 vet support—helping your horse stay sound and active in 2025. 🐴💊