Feline Myelomalacia: A Vet’s 2025 Guide to Spinal Cord Softening, Diagnosis & Care 🧠🐾

Hello, I’m Dr. Duncan Houston BVSc, veterinarian and founder of Ask A Vet. In 2025, we understand myelomalacia—a progressive “softening” and necrosis of spinal cord tissue—more clearly. In this comprehensive guide, we’ll explore causes, signs, diagnosis (especially MRI), prognosis, options for palliation or euthanasia, and compassionate care strategies for affected cats.

📘 What Is Myelomalacia?

Myelomalacia refers to necrosis (cell death) and softening of spinal cord tissue, often with hemorrhage. It may progress cranially (ascending), caudally (descending), or stay focal. In cats, it's most often caused by severe spinal cord injury—from trauma, vascular events (FCE), injection mishaps, disc herniation, or tumors. This condition is irreversible and fatal if widespread :contentReference[oaicite:3]{index=3}.

🐾 Who Is at Risk?

• Any cat with **severe spinal cord trauma**, such as bite wounds, fractures, or disc injuries :contentReference[oaicite:4]{index=4}.
• Cats suffering **fibrocartilaginous embolism (FCE)** or ischemic spinal events :contentReference[oaicite:5]{index=5}.
• Cats with **intraspinal injection trauma**—e.g., accidental thoracic injection leading to hemorrhage :contentReference[oaicite:6]{index=6}.
• Cats with **spinal tumors**, such as lymphoma compressing and interrupting cord blood supply :contentReference[oaicite:7]{index=7}.

⚠️ Recognizing the Signs

Initially, cats may present with:

• Acute paraplegia or severe paresis below the lesion
• Loss of deep pain sensation
• Loss of reflexes (areflexia) in hind limbs and tail
• Absent anal tone or bladder control

If the necrosis spreads cranially, signs worsen: trunk muscle tone fails (cutaneous trunci reflex recedes), breathing muscles can be affected—leading to respiratory distress and collapse :contentReference[oaicite:8]{index=8}. This progression often occurs within hours to days of the initial injury.

🧭 Diagnosis

1. Clinical Neurological Exam

• Neurologic localization pinpoints lesion at T3–L3 or other cord segments
• Presence or absence of deep pain is crucial for prognosis
• Serial exams may reveal ascending deficits—warning sign of progressive necrosis

2. MRI / Myelography

MRI is the gold standard. T2-weighted images show hyperintensity along the lesion; presence of hemorrhage (signal voids) is concerning :contentReference[oaicite:9]{index=9}. Progressive swelling, contrast leakage, or elongated lesions typically indicate myelomalacia :contentReference[oaicite:10]{index=10}.

3. CSF Analysis

Spinal taps may show xanthochromia, neutrophils, or elevated protein—particularly hemorrhagic or necrotic pattern :contentReference[oaicite:11]{index=11}. These findings add diagnostic confidence.

4. Histopathology

True confirmation requires post-mortem exam, showing cavitation, hemorrhage, and tissue necrosis—usually not required if clinical diagnosis is clear.

📚 Causes & Case Examples

One dramatic case involved a juvenile cat receiving an intra-spinal injection by mistake, later developing ascending myelomalacia from T10 to L1—with hemorrhage seen on MRI and confirmed necrosis on histology :contentReference[oaicite:12]{index=12}. Another case involved extradural T-cell lymphoma causing hemorrhagic myelomalacia from T2–L3 :contentReference[oaicite:13]{index=13}.

📈 Prognosis

Unfortunately, prognosis is poor:

• Once necrosis ascends above T10–L1, fatal respiratory compromise is almost inevitable :contentReference[oaicite:14]{index=14}.
• Any cat losing deep pain perception with progressive deficits has a grave outlook.
• No treatments reverse necrosis; supportive care only delays progression marginally :contentReference[oaicite:15]{index=15}.
• Statistics from traumatic spinal cord injury in cats show many with deep pain loss go on to develop myelomalacia :contentReference[oaicite:16]{index=16}.

🛠️ Management & Care

While no curative therapy exists, compassionate supportive care may be offered early:

• Prevent pressure sores—regular repositioning, padded bedding
• Bladder care—manual expression or catheterization, hygiene
• Pain management—opioids as needed, comfort focus
• Nutrition—assist feeding or nutritional support when needed
• Physiotherapy—passive limb movement; though with necrosis, utility is limited

⚖️ When to Consider Euthanasia

• Loss of deep pain and ascending signs reaching cervical cord → likely respiratory failure
• Severe distress or poor quality of life
• Persistent pain, inability to stand, loss of bladder/bowel function
• Ask A Vet can assist with symptom management and guide quality-of-life scoring tools

💡 Helping Families Cope

• Provide clear explanations of prognosis and time course
• Use quality-of-life scales (app available via Ask A Vet)
• Support emotional decisions—palliative care until euthanasia is humane
• Refer for hospice if appropriate

### Summary

Myelomalacia is irreversible spinal cord necrosis in cats, typically resulting from severe trauma or vascular events. Diagnosis relies on MRI and clinical exams. Once necrosis ascends, prognosis is grave. Supportive care can delay progression, but euthanasia is often the kindest option when neurological decline is evident. The Ask A Vet app provides guided care tools, comfort planning, and compassionate advice during these difficult times 🐱❤️.

For personalized support, Q&A, or end-of-life guidance, visit AskAVet.com or download the Ask A Vet app. We’re here to help you and your feline friend with empathy, clarity, and veterinary expertise. 🐾