Proliferative Bowel Disease in Ferrets: A Vet’s 2025 Guide to Causes, Diagnosis & Recovery 🐾🩺

By Dr Duncan Houston BVSc – exotic‑pet veterinarian & founder of Ask A Vet 🩺

Proliferative Bowel Disease (PBD), also known as proliferative colitis or ileitis, is caused by the intracellular bacterium Lawsonia intracellularis. Primarily affecting young, growing ferrets aged 10–16 weeks, it leads to abnormal thickening of the lower intestine and severe clinical signs. Prompt recognition and treatment can prevent serious complications and mortality.

1. 🔬 What Is Proliferative Bowel Disease?

• PBD is due to Lawsonia intracellularis invading the cells of the ileum and colon, causing mucosal hyperplasia and dysfunction :contentReference[oaicite:3]{index=3}.
• The condition leads to thickened intestinal walls that impair nutrient and fluid absorption.

2. 🧬 Who’s at Risk?

• Rapidly growing kits aged ~10–16 weeks; sometimes older, immunocompromised ferrets :contentReference[oaicite:4]{index=4}.
• Stressors like poor housing, poor diet, multi‑ferret environments increase risk :contentReference[oaicite:5]{index=5}.
• Occurs less often today in well‑cared‑for pet ferrets but remains a significant threat during kittenhood :contentReference[oaicite:6]{index=6}.

3. ⚠️ Signs & Clinical Features

• Chronic diarrhea—often dark, mucus‑streaked, occasionally blood‑tinged :contentReference[oaicite:7]{index=7}.
• Straining to defecate, tenesmus, with moaning or vocalizing; rectal prolapse may occur :contentReference[oaicite:8]{index=8}.
• Rapid weight loss despite appetite, dehydration, lethargy :contentReference[oaicite:9]{index=9}.
• Palpable thickened bowel on physical exam :contentReference[oaicite:10]{index=10}.
• Bacterial invasion (Campylobacter-like) seen in lymph nodes from histology :contentReference[oaicite:11]{index=11}.

4. 🩺 How Is It Diagnosed?

• Clinical signs in young kits are strongly suggestive :contentReference[oaicite:12]{index=12}.
• Physical palpation may detect thickened intestines.
• PCR testing of rectal swabs or feces confirms Lawsonia presence :contentReference[oaicite:13]{index=13}.
• Colonic biopsy and histopathology is definitive—identifies mucosal hyperplasia and intracellular bacteria :contentReference[oaicite:14]{index=14}.

5. 🛠 Treatment Protocol

A. Antibiotic Therapy

• Chloramphenicol is the primary treatment: 50 mg/kg PO or IM every 12 hr for 10–21 days :contentReference[oaicite:15]{index=15}.
• Alternatives include amoxicillin, clarithromycin, doxycycline, or metronidazole for supportive care :contentReference[oaicite:16]{index=16}.

B. Supportive Care

• Fluids (IV or SC) for dehydration :contentReference[oaicite:17]{index=17}.
• Nutritional support: high-calorie foods like kitten canned food, Nutrical, or liquid diets :contentReference[oaicite:18]{index=18}.
• Gastroprotectants: omeprazole or sucralfate to protect inflamed mucosa :contentReference[oaicite:19]{index=19}.
• Anti‑emetics and GI motility agents including metoclopramide or cisapride as needed :contentReference[oaicite:20]{index=20}.
• Rectal prolapse generally resolves with medical treatment; surgery rarely required :contentReference[oaicite:21]{index=21}.

6. 🏡 Recovery & Home Care

• Monitor fecal output, appetite, weight, hydration daily.
• Continue medications as prescribed and complete full antibiotic course.
• Maintain a clean environment—frequent bedding and cage cleaning reduces reinfection risk :contentReference[oaicite:22]{index=22}.
• Gradually reintroduce balanced diet after symptoms improve.
• Minimize stressors, avoid overcrowding.
• Use Ask A Vet for medication reminders, hydration logs, and early warning notifications via app or AskAVet.com.

7. 📊 Quick Reference Table

8. 🧡 Final Takeaways

• PBD is a serious but treatable intracellular bacterial disease—early detection saves lives.
• Watch for mucus or blood-tinged diarrhea, straining, rapid weight loss in young kits.
• Diagnosis via clinical evaluation, PCR, and biopsy; prompt treatment with chloramphenicol and support yields the best results.
• Proper hydration, nutrition, gastroprotection, and hygiene are essential for recovery.
• Ask A Vet provides guidance on dosing, symptom tracking, follow-up care, and environmental strategies—via app or AskAVet.com. 🐾

If your ferret shows persistent diarrhea, straining, or weight loss, seek veterinary care without delay. Early treatment optimizes recovery and avoids irreversible damage. Use the Ask A Vet app for tailored care plans, medication reminders, and expert support. 🩺🐾