Prostatitis in Cats: A Vet’s 2025 Guide to Diagnosis, Treatment & Long-Term Support 🐱🩺

Hi, I’m Dr. Duncan Houston BVSc, veterinarian and founder of Ask A Vet. In this 2025 guide, we’re taking a closer look at prostatitis in cats—a rare but medically significant condition involving inflammation or infection of the prostate gland. Although uncommon compared to dogs, prostatitis in male cats can lead to urinary difficulty, fever, discomfort, and—in severe cases—life-threatening abscesses or systemic infection. Let’s cover what to watch for, how we diagnose and treat it, and how you can support your cat’s long-term comfort and urinary health.

📘 1. What Is Prostatitis?

Prostatitis refers to inflammation of the prostate gland, typically due to bacterial infection but occasionally secondary to trauma, urethral obstruction, or neoplasia. In cats, this is exceptionally rare because the feline prostate is small and less hormone-dependent than in dogs. However, when it occurs, it’s often serious.

📊 2. Risk Factors & Underlying Causes

• Unneutered (intact) male cats—prostate is hormonally active.
• Secondary to urinary tract infections (UTIs) or urethral obstruction.
• Post-trauma or catheterization injury.
• Rarely, associated with prostate abscess, tumors, or systemic disease.

👀 3. Symptoms of Feline Prostatitis

Signs can be subtle or severe, including:

• Straining to urinate or defecate (tenesmus)
• Blood in the urine (hematuria)
• Urinating outside the litter box, frequent urination
• Fever, lethargy, decreased appetite
• Stiff gait, back pain, or vocalizing when handled
• In severe cases: systemic illness, sepsis, or prostate abscess

🔬 4. Diagnostic Workup

1. Physical exam: rectal palpation (if tolerated) may reveal an enlarged, firm, or painful prostate.
2. Bloodwork: CBC, biochemistry to check for inflammation, organ dysfunction, or dehydration.
3. Urinalysis: check for WBCs, RBCs, bacteria; culture & sensitivity is essential.
4. Imaging: abdominal ultrasound is the gold standard—can visualize prostate size, texture, abscesses, or masses.
5. Prostatic fluid aspiration: for cytology and culture, done under sedation if needed.

🛠️ 5. Treatment Options

💊 Antibiotics

• Begin empirical therapy after culture submission (e.g., enrofloxacin, marbofloxacin, or doxycycline).
• Adjust based on sensitivity results.
• Duration: 4–6 weeks minimum; some cases require longer courses.

🧊 Pain & Inflammation Control

• NSAIDs (meloxicam, robenacoxib) if kidney function allows.
• Opioids for more severe discomfort.

💉 Supportive Care

• Fluids for hydration and to flush urinary tract.
• Appetite stimulants, probiotics if anorexia or antibiotic side effects occur.

🧪 Abscess or Severe Cases

• Surgical drainage or ultrasound-guided aspiration if abscesses develop.
• Hospitalization and IV therapy may be required.

✂️ Neutering

Neutering may help reduce recurrence and is generally recommended once stable—especially in intact males.

📈 6. Monitoring & Prognosis

• Monitor fever, appetite, urine habits, and comfort levels.
• Recheck ultrasound or palpation after 4–6 weeks.
• Repeat culture if symptoms persist or return.
• Prognosis is good if treated early and aggressively.

🏡 7. Home Care & Recovery

• Ensure litter box access—multiple boxes in quiet spots.
• Maintain a high-moisture diet (wet food, water fountains).
• Administer all medications exactly as directed—set reminders in the Ask A Vet app.
• Track urination frequency, volume, and any blood or straining.

📚 8. Case Example

“Jasper,” an 8-year-old neutered DSH, presented with fever, hematuria, and back pain. Urine culture grew E. coli. Ultrasound revealed a hypoechoic, enlarged prostate. Treated with marbofloxacin and pain relief for 6 weeks. Recheck imaging showed normalization, and Jasper fully recovered.

🚨 9. When to Contact the Vet

• Persistent straining to urinate or defecate
• Fever or signs of systemic illness
• Visible blood in urine or recurring infections
• Unresponsive to medications or worsening signs

✨ 10. Final Thoughts

Feline prostatitis, though rare, can cause serious urinary, systemic, and reproductive issues if left untreated. With modern diagnostics, proper antimicrobial use, and thoughtful support, most cats recover well. Ask A Vet supports you with daily tracking tools, symptom logs, prescription reminders, and tele-support to guide healing every step of the way. 🐾❤️

For personalized treatment plans, imaging follow-ups, or urinary symptom tracking, visit AskAVet.com or download the Ask A Vet app. We’re with you every day of the recovery journey.