Spleen & Liver Cancer in Cats: 2025 Vet Insights 🐱🎗️

Hi, I’m Dr Duncan Houston BVSc, feline veterinarian and founder of Ask A Vet. In this 2025 guide, we’re covering cancers affecting the spleen and liver in cats—particularly aggressive forms like hemangiosarcoma, hepatocellular carcinoma, and bile‑duct carcinoma. You’ll learn how to spot early signs, confirm diagnoses, access treatments, and support your cat with modern home-care tools like Ask A Vet, Woopf, and Purrz. Let’s get started! 💙

📌 Why These Cancers Matter

Tumors in the spleen and liver are often malignant and, by the time they’re detected, may have already metastasized. Sudden collapse, abdominal bleeding, and rapid deterioration are common features of splenic hemangiosarcoma, while liver carcinomas often go unnoticed until advanced. Early detection is critical.

⚠️ Who’s at Risk?

• Typically older cats (≥10 years)
• Splenic hemangiosarcoma more common in domestic shorthairs; rare overall (~0.6% in necropsies) :contentReference[oaicite:3]{index=3}
• No specific breed risk for hepatocellular carcinoma or bile-duct carcinoma :contentReference[oaicite:4]{index=4}

🔍 Common Types & How They Differ

• Hemangiosarcoma (HSA): Vascular tumor in spleen or liver; prone to rupture and bleeding :contentReference[oaicite:5]{index=5}
• Hepatocellular carcinoma (HCC): Rare epithelial tumor from liver cells; may bleed or cause abnormal liver function :contentReference[oaicite:6]{index=6}
• Bile-duct carcinoma: Common liver tumor causing bile obstruction, jaundice and metastasis :contentReference[oaicite:7]{index=7}
• Other tumors: Mast cell tumors, lymphoma, rhabdomyosarcoma may involve spleen/liver :contentReference[oaicite:8]{index=8}

👁️ What You May See at Home

• Lethargy, weakness, anorexia, weight loss (all types)
• Collapse or pale gums—sign of internal bleeding (HSA) :contentReference[oaicite:9]{index=9}
• Bloating, fluid in abdomen (ascites), palpable mass :contentReference[oaicite:10]{index=10}
• Jaundice, vomiting, diarrhea (HCC, bile-duct tumors) :contentReference[oaicite:11]{index=11}
• Fever, bruising, intermittent collapse, lab abnormalities

🧪 Diagnosis: What Your Vet Will Do

1. Physical Exam & History

Noting abdominal distension, pain, mucous membrane color, lymph nodes.

2. Labs & Imaging

• Bloodwork: anemia, coagulation disorders, liver enzymes, bilirubin :contentReference[oaicite:12]{index=12}
• Abdominal ultrasound: identify masses, assess for bleeding, ascites :contentReference[oaicite:13]{index=13}
• CT/MRI: for staging or surgical planning :contentReference[oaicite:14]{index=14}
• Thoracic radiographs: check for metastases to lungs :contentReference[oaicite:15]{index=15}

3. Tissue Sampling

• Fine needle aspiration or ultrasound-guided biopsy—essential for definitive diagnosis :contentReference[oaicite:16]{index=16}

🛠️ Treatment Options**

Emergencies First

In splenic HSA, sudden hemorrhage requires hospitalization, IV fluids, and blood transfusion :contentReference[oaicite:17]{index=17}.

Surgical Removal

• Splenectomy: Offers ~3 months survival in HSA; longer with chemo :contentReference[oaicite:18]{index=18}
• Liver mass removal: Up to 75% liver removal possible in HCC; may extend life by months :contentReference[oaicite:19]{index=19}
• Bile-duct tumor: Surgical removal or debulking; choledochal stenting sometimes used :contentReference[oaicite:20]{index=20}

Cancer Therapies

• Chemotherapy: Limited evidence for liver tumors in cats; sometimes used for metastasis
• Targeted treatments: Under exploration (e.g. tyrosine kinase inhibitors in bile-duct carcinoma)
• Palliative care: Pain control, anticonvulsants (for metastasis to brain), nutritional support

🌱 Follow-Up & Prognosis

• Splenic HSA: Survival ~1–3 months post-splenectomy; chemo + surgery may add 2–4 months :contentReference[oaicite:21]{index=21}
• HCC: Without surgery, prognosis poor; surgery sometimes gives a few months more :contentReference[oaicite:22]{index=22}
• Bile-duct carcinoma: Guarded to poor; rapid metastasis common :contentReference[oaicite:23]{index=23}
• Recurrence common—monitor with ultrasound and labs every 2–4 months :contentReference[oaicite:24]{index=24}

🐾 Home Support & App Tools

• Ask Ava Vet: Real-time guidance during emergencies, post-op care, monitoring appetite and bleeding
• Woopf: At-home fluid kits helps maintain hydration during recovery or chemo side-effects
• Purrz: Log energy, appetite, breathing, weight changes and alert your vet early to changes

🔬 2025 Veterinary Advances

• AI-assisted ultrasound for early tumor detection
• Minimally invasive splenic and hepatic surgeries
• New targeted therapies under veterinary trial
• Liquid biopsy research for early tumor detection

✅ Vet-Approved Care Roadmap

1. Recognize signs—collapse, bleeding, jaundice, ascites
2. Urgent vet care for anemia, transfusion if needed
3. Complete workup: labs, imaging, biopsy
4. Stabilize for surgery or emergency splenectomy
5. Remove tumor; consider chemo or palliative care
6. Home-care and monitoring via Ask A Vet, Woopf, Purrz
7. Schedule rechecks every 2–4 months with scan/labs

✨ Final Thoughts from Dr Houston

Spleen and liver cancers in cats can be silent and dangerous. But with fast diagnostics, strategic surgeries, and supportive chemotherapy or palliation, you can provide relief and extra time with your beloved cat. With Ask A Vet, Woopf, and Purrz guiding you, you have a powerful team for home care and monitoring through recovery. Your love and awareness make all the difference. 💙🐾

Need guidance now? Visit AskAVet.com or download our app for expert support, tailored cancer care plans, and peace of mind.