Vet Guide to Credelio® (Lotilaner) in 2025 🐾

Hello, I’m Dr Duncan Houston BVSc—founder of Ask A Vet. This comprehensive 2025 guide focuses on Credelio®, a monthly chewable tablet of lotilaner approved for dogs and puppies (≥ 8 weeks, ≥ 4.4 lb) to treat and prevent fleas and ticks. Learn how it works, proper dosing, onset and duration, safety tips, side effects, and veterinary monitoring for optimal parasite control. 🐶🛡️

📘 What Is Credelio®?

Credelio® contains lotilaner, an isoxazoline-class antiparasitic that targets insect nervous systems via GABA‑gated chloride channels, leading to paralysis and death of fleas and ticks :contentReference[oaicite:3]{index=3}.

It’s FDA-approved for monthly protection against fleas and multiple tick species—including lone star, American dog, black-legged, and brown dog ticks :contentReference[oaicite:4]{index=4}.

✅ Why Use Credelio®?

• Rapid flea and tick kill: ≥ 99% fleas within 8 hours, 100% by 12 hours; tick efficacy is equally strong :contentReference[oaicite:5]{index=5}.
• Helps control flea allergy dermatitis and reduces vector-borne disease risk.
• Convenient monthly bite‑sized chewable—easy to give and palatable :contentReference[oaicite:6]{index=6}.

📐 Dosing Instructions

• Administer orally once a month—minimum dose of 9 mg/lb (20 mg/kg) with food or within 30 minutes after a meal :contentReference[oaicite:7]{index=7}.
• Weight ranges and tablet sizes:
  • 4.4–6 lb: 56.25 mg
  • 6.1–12 lb: 112.5 mg
  • 12.1–25 lb: 225 mg
  • 25.1–50 lb: 450 mg
  • 50.1–100 lb: 900 mg
  • >100 lb: combination tablets to meet dose :contentReference[oaicite:8]{index=8}.
• If you miss a dose, administer as soon as you remember and continue monthly schedule :contentReference[oaicite:9]{index=9}.

⏱️ Onset & Duration of Effect

Credelio® begins killing fleas as soon as 4 hours post-dose and sustains near-complete adult flea control through 30 days :contentReference[oaicite:10]{index=10}.

Ticks are eliminated within days, with protection lasting the full month.

⚠️ Safety & Side Effects

Common mild effects:

• Vomiting, diarrhea, inappetence, weight loss, increased urination :contentReference[oaicite:11]{index=11}.
• Elevated BUN or creatinine in rare geriatric cases :contentReference[oaicite:12]{index=12}.
• Dermatitis or mild hair coat changes :contentReference[oaicite:13]{index=13}.

Neurological concerns:

Isoxazolines, including lotilaner, have been linked to rare neurologic events like tremors, incoordination, and seizures—even in pets without prior signs :contentReference[oaicite:14]{index=14}.

Use cautiously or avoid in dogs with seizure history or neurologic disorders :contentReference[oaicite:15]{index=15}.

🚫 Contraindications & Precautions

• Not evaluated in breeding, pregnant, or lactating dogs—discuss risk vs. benefit with your vet :contentReference[oaicite:16]{index=16}.
• Always administer with food—fasted use lowers absorption :contentReference[oaicite:17]{index=17}.
• Ensure tablet is fully consumed; store in blister pack at room temperature :contentReference[oaicite:18]{index=18}.

🩺 Monitoring & Vet Follow‑Up

• No routine lab monitoring required, but vets may recommend periodic bloodwork—especially in senior dogs :contentReference[oaicite:19]{index=19}.
• Monitor for GI upset, coat changes, neurologic signs post-dose.
• Contact your vet immediately if tremors, seizures, persistent vomiting, or severe diarrhea appear.

⏳ Missed Dose & Overdose Guidelines

• For missed dose, give as soon as possible, then resume your regular monthly schedule :contentReference[oaicite:20]{index=20}.
• Overdose symptoms (vomiting, lethargy, neurologic signs): contact vet or poison control :contentReference[oaicite:21]{index=21}.

🏡 Real‑World Case Examples

🐶 Healthy Adult Dog During Flea Season

• Start Credelio® monthly with breakfast for seasonal prevention.
• Monitor for adverse effects after first 24–48 hours, then continue month-to-month.

🐶 Senior Dog With Kidney Concerns

• Vet may perform baseline BUN/creatinine before first dose.
• Monitor for inappetence or increased thirst; consider alternate products if needed.

❓ Frequently Asked Questions

Can Credelio® be used year‑round?

Yes—especially in regions with year-round flea or tick exposure and breeds prone to flea allergy.

How does it compare to NexGard or Bravecto?

Each uses a different isoxazoline (afoxolaner or fluralaner). Credelio® works quickly and shares similar safety profile—choose based on pet health, dosing preference, and veterinary advice.

Is Credelio® safe for puppies?

Yes—approved for puppies ≥ 8 weeks and ≥ 4.4 lb; weight should be monitored monthly for dose adjustments :contentReference[oaicite:22]{index=22}.

📌 Final Takeaways

• Credelio® is a monthly oral chewable of lotilaner for fast, reliable flea and tick control.
• Administer with food at 9 mg/lb (20 mg/kg) once monthly.
• Common mild effects include GI upset or coat changes; rare neurologic events should be monitored for.
• Use cautiously in pets with seizure histories; evaluate suitability in breeding animals.
• Combined with environmental control, Credelio® supports a thorough parasite prevention plan.

Interested in protecting your dog with Credelio®? Download the Ask A Vet app for dosing reminders, parasite tracking, and 24/7 veterinary support—let’s keep your dog safe and itch-free! 🐾❤️