Veterinary 2025 Guide: Metoclopramide for Nausea & GI Motility in Dogs & Cats 🐾🩺

Greetings! I’m Dr Duncan Houston BVSc. This comprehensive 2025 guide explores the veterinary use of metoclopramide (Reglan®)—a dopamine receptor antagonist and prokinetic agent used to manage nausea, vomiting, reflux, and motility disorders in dogs and cats. You'll discover its mechanisms, dosing protocols, side effects, contraindications, monitoring guidelines, and client communication strategies, with support tools built into Ask A Vet 😊.

🔎 1. What Is Metoclopramide?

Metoclopramide is both a central antiemetic and peripheral gastrointestinal prokinetic. Its dual action—stimulating gastric emptying and blocking dopamine-2 receptors in the chemoreceptor trigger zone—makes it effective against vomiting, gastroparesis, reflux, ileus, and esophagitis :contentReference[oaicite:3]{index=3}.

🎯 2. Indications & Uses in 2025

• Acute or chronic vomiting, especially from chemotherapy, parvovirus enteritis, renal or hepatic disease :contentReference[oaicite:4]{index=4}.
• Gastroesophageal reflux and esophagitis in dogs.
• Delayed gastric emptying (gastroparesis) or ileus post-op :contentReference[oaicite:5]{index=5}.
• Reflux prevention in tube-fed or recumbent pets.

💊 3. Dosage Guidelines

• Typical dose: **0.2–0.5 mg/kg PO, IV, IM, or SC every 6–8 hours**; can be given with fluid therapy :contentReference[oaicite:6]{index=6}.
• Injectable dose: **0.1–0.25 mg/lb (≈0.2–0.5 mg/kg)** TID-QID :contentReference[oaicite:7]{index=7}.
• Best given 20 minutes before meals to maximize motility effect :contentReference[oaicite:8]{index=8}.
• Infusion protocol: **0.1–0.2 mg/kg/hr** in fluids for continuous therapy :contentReference[oaicite:9]{index=9}.

⏳ 4. Onset & Duration

Onset occurs in 30–60 minutes via any route; duration lasts around 6–8 hours depending on renal and hepatic function :contentReference[oaicite:10]{index=10}.

⚠️ 5. Side Effects & Risks

• Common: Restlessness, hyperactivity, tremors or twitching, drowsiness, constipation, increased urination :contentReference[oaicite:11]{index=11}.
• Serious: Neurological signs including aggression, incoordination; serotonin syndrome possible in overdoses :contentReference[oaicite:12]{index=12}.
• Signs typically resolve within days of discontinuation :contentReference[oaicite:13]{index=13}.

🚫 6. Contraindications & Precautions

• Do **not use** in cases of GI obstruction, perforation, hemorrhage, or recent GI surgery :contentReference[oaicite:14]{index=14}.
• Avoid in seizure-prone pets—may lower seizure threshold :contentReference[oaicite:15]{index=15}.
• Contraindicated in pheochromocytoma due to catecholamine release risk :contentReference[oaicite:16]{index=16}.
• Use with caution in liver or kidney disease—dose adjust as needed :contentReference[oaicite:17]{index=17}.
• Avoid long-term (>12 weeks) due to risk of extrapyramidal movement disorders :contentReference[oaicite:18]{index=18}.

🧩 7. Drug Interactions

Potential interactions with serotonergic drugs (e.g., SSRIs), other CNS depressants, and substances affecting CYP metabolism. Consider when combined with phenothiazines, opioids, or antihistamines :contentReference[oaicite:19]{index=19}.

📋 8. Monitoring & Vet Follow‑Up

• Monitor appetite, vomiting frequency, behavior, and urinary habits daily.
• Neurologic signs or aggression signals warrant immediate cessation.
• Labs aren’t routine but assess kidney and liver function if long-term use is considered.

💡 9. Client Education & Home Care

• Show proper dosing routes and timing relative to meals.
• Coach owners to monitor and report restlessness, shake, or aggression.
• Advise against use if vomiting with abdominal pain or signs of obstruction.
• Recommend Ask A Vet app for reminders, symptom tracking, and direct vet messaging 😊.

📌 10. 2025 Vet Takeaways

• Metoclopramide is a versatile antiemetic and prokinetic essential in treating GI disorders in pets.
• Dosage: 0.2–0.5 mg/kg multiple times daily, routes flexible.
• Avoid in obstruction or seizure-risk patients; monitor for CNS signs.
• Support owners with clear instructions and use app-based tools to improve compliance and safety 😊.

At Ask A Vet, we offer dosing timers, behavioral side-effect alerts, GI symptom logs, and 24/7 vet access to ensure safe, effective use of metoclopramide in your practice. Download our app to support confident, responsive care ❤️