Veterinary 2025 Guide: Potassium Bromide (K-BroVet®) for Canine Epilepsy 🐾🩺

Hello, I’m Dr Duncan Houston BVSc. In this 2025 guide, we cover potassium bromide—a long‑standing adjunct or monotherapy for canine epilepsy, available as K‑BroVet® liquid or K‑BroVet‑CA1® chewable tablets. We'll explore how it works, dosing strategies (including loading vs. maintenance), side effects, monitoring, dietary considerations, and owner support tools via Ask A Vet 😊.

🔍 1. What Is Potassium Bromide?

A prescription anticonvulsant for dogs, available as flavored chewables (K‑BroVet‑CA1®, FDA conditionally approved) or oral solution with B12/B6 (K‑BroVet®). It’s not approved for cats and should be avoided in them due to lung disease risk :contentReference[oaicite:3]{index=3}.

⚙️ 2. Mechanism of Action

Upon ingestion, bromide ions replace chloride in CNS neurons, stabilizing neuronal membranes and raising seizure threshold :contentReference[oaicite:4]{index=4}.

💊 3. Dosing & Administration

• Loading dose (optional): 40–60 mg/kg BID for 5 days (e.g., 600 mg/kg over 5 d) to rapidly reach therapeutic levels :contentReference[oaicite:5]{index=5}.
• Maintenance dose: Monotherapy: 25–40 mg/kg once daily; adjunct to phenobarbital: 15–30 mg/kg once daily :contentReference[oaicite:6]{index=6}.
• Flavored tablets or liquid—both may be given with or without food to reduce GI upset :contentReference[oaicite:7]{index=7}.
• If a dose is missed, administer when remembered unless it's near next scheduled dose—do not double-dose.

⏱️ 4. Onset & Pharmacokinetics

Long half‑life (~12 days) means steady state achieved after several months unless loading dose used. Loading speeds onset; maintenance dosing sustains levels :contentReference[oaicite:8]{index=8}.

⚠️ 5. Side Effects & Precautions

• Common: sedation, ataxia, polydipsia/polyuria, weight gain, increased appetite—often mild and adapt over time :contentReference[oaicite:9]{index=9}.
• GI upset occasionally; vomiting/diarrhea may respond to dose with food :contentReference[oaicite:10]{index=10}.
• Serious: bromide toxicity – tremors, stupor, seizures; pancreatitis possible when combined with phenobarbital :contentReference[oaicite:11]{index=11}.
• Avoid in cats (pneumonitis risk), renal disease, or diuretics (affect bromide levels) :contentReference[oaicite:12]{index=12}.

🩺 6. Monitoring & Re‑Evaluation

• Check serum bromide levels: at 1 mo post-maintenance, then every 3–6 mo :contentReference[oaicite:13]{index=13}.
• Also monitor renal/hepatic profiles and seizure frequency.
• Adjust dose based on levels and side effects.

🥗 7. Dietary & Drug Interactions

• High or low salt intake alters bromide excretion—maintain consistent chloride intake :contentReference[oaicite:14]{index=14}.
• Diuretics (e.g., furosemide) and sedatives may interact—warn owners to report any co‑medications :contentReference[oaicite:15]{index=15}.

📝 8. Client Education & Home Guidance

• Explain chronic therapy timeline and need for blood monitoring.
• Show proper administration—link tablets or liquid—emphasize giving with food if GI upset occurs.
• Highlight side effects—report sedation, ataxia, appetite changes, GI signs, or respiratory concerns.
• Warn against altering dietary salt, sudden dose changes, or abrupt discontinuation.
• Recommend Ask A Vet app for medication reminders, symptom tracking, lab alerts, and 24/7 vet messaging 😊.

📌 9. 2025 Vet Takeaways

• Potassium bromide remains an effective option for canine epilepsy, as monotherapy or with phenobarbital.
• Incorporate loading dose to expedite control, then transition to maintenance (~25–40 mg/kg daily).
• Side effects are common but often manageable; serious risks require vigilance.
• Maintain consistent chloride intake and monitor blood levels regularly.
• Clear owner education and digital follow-up via Ask A Vet improve outcomes 😊.

At Ask A Vet, we offer seizure log trackers, dosing reminders, blood-level alerts, and 24/7 messaging support to help owners confidently manage epilepsy. Encourage clients to download our app for continuous care ❤️