Veterinary 2025 Guide: Prednisone & Prednisolone for Dogs & Cats 🐾🩺

Hello, I’m Dr Duncan Houston BVSc. This 2025 guide explores **prednisone** and **prednisolone**—two widely prescribed human corticosteroids frequently used off-label in dogs and cats for inflammatory, allergic, autoimmune, and endocrine conditions. You'll find pharmacology, dosing, tapering protocols, side effects, monitoring tips, and client support advice through Ask A Vet 😊.

🔍 1. What Are These Drugs?

These are glucocorticoids—steroid hormones that reduce inflammation, suppress immune function, and alter metabolism. Dogs can convert prednisone to active prednisolone, but cats require prednisolone directly due its limited conversion capacity :contentReference[oaicite:3]{index=3}.

🎯 2. Indications in 2025

• Inflammatory diseases (arthritis, dermatitis, inflammatory bowel disease, asthma).
• Autoimmune disorders (hemolytic anemia, thrombocytopenia).
• Allergies (atopic dermatitis, anaphylaxis).
• Endocrine therapy (Addison’s disease replacement) and part of certain chemo protocols :contentReference[oaicite:4]{index=4}.

💊 3. Dosing & Administration

• Dogs: **0.5–2 mg/kg/day**, depending on condition & dosing regimen.
• Cats: **0.5–1 mg/kg/day** with prednisolone (not prednisone).
• Administer with food to minimize GI upset. Always follow vet guidance precisely :contentReference[oaicite:5]{index=5}.
• Missed dose? Give when recalled unless it's near next scheduled dose; do **not** double up :contentReference[oaicite:6]{index=6}.
• Taper gradually over days to weeks after >1–2 weeks’ use—abrupt cessation risks adrenal crisis :contentReference[oaicite:7]{index=7}.

⚠️ 4. Common Side Effects

• Increased thirst, urination, appetite, panting, weight gain, and muscle wasting :contentReference[oaicite:8]{index=8}.
• GI signs: vomiting, diarrhea; ulceration risk, particularly with concurrent NSAID use :contentReference[oaicite:9]{index=9}.
• Behavior changes: restlessness, aggression, lethargy—sometimes seen with steroid use :contentReference[oaicite:10]{index=10}.
• Long-term risks: diabetes exacerbation, Cushing’s-like signs (pot-belly, skin thinning, infections) :contentReference[oaicite:11]{index=11}.

🚫 5. Precautions & Drug Interactions

• Avoid in systemic infections, corneal ulcers, GI ulceration, and uncontrolled diabetes or heart disease :contentReference[oaicite:12]{index=12}.
• Never combine with NSAIDs—high GI-bleed risk :contentReference[oaicite:13]{index=13}.
• Inform your vet about all medications/supplements, as they can interact or alter metabolism/performance :contentReference[oaicite:14]{index=14}.

🩺 6. Monitoring & Follow‑Up

• Regularly assess clinical signs (appetite, thirst, urination, behaviour).
• Perform periodic blood tests—CBC, chemistry, urinalysis—including blood pressure if on long-term steroids :contentReference[oaicite:15]{index=15}.
• Monitor thyroid, kidney, liver, and endocrine function during chronic therapy.

📝 7. Client Education & Home Care

• Explain purpose, tapering necessity, and distribution with food.
• Demonstrate dosing accuracy and proper storage at 68–77 °F, away from moisture.
• Prepare them for predictable side effects and signs needing vet attention (bleeding, infection, GI distress, behaviour changes).
• Recommend Ask A Vet app for medication reminders, side-effect tracking, lab reminders, and 24/7 assistance 😊.

📌 8. 2025 Vet Takeaways

• Prednisone and prednisolone remain essential tools for managing inflammation, immune disorders, and endocrine diseases.
• Strict dosing and tapering protocols reduce risk of adverse effects.
• Monitor patients closely for systemic side effects and interactively adjust plan.
• Client education with digital support ensures safer, more successful outcomes 😊.

At Ask A Vet, we provide dosing guides, tapering trackers, symptom alerts, and lab-visit reminders—plus 24/7 messaging support to ensure safe, effective steroid therapy. Encourage your clients to download our app for confident home care ❤️