💉 Zimeta Vet Guide 2025 by Dr Duncan Houston

Welcome to this advanced veterinary reference on Zimeta® (dipyrone injection), designed for equine practitioners and informed owners. This guide provides a comprehensive overview of its **indications**, **dosing protocols**, **safety precautions**, **side effects**, and **recommended monitoring** to optimize fever management in horses. 🐴✨

📌 What Is Zimeta?

Zimeta® is the first FDA-approved injectable pyrazolone-class NSAID for horses, containing **500 mg/mL dipyrone sodium** in a sterile IV solution. Each milliliter also contains **10 mg benzyl alcohol** as a preservative :contentReference[oaicite:2]{index=2}. Dipyrone is rapidly converted to its active metabolite, 4-MAA, which lowers fever by acting on central COX pathways in the hypothalamus :contentReference[oaicite:3]{index=3}.

🎯 Indications

Zimeta® is indicated for **management of pyrexia (fever)** secondary to infectious or inflammatory conditions in horses. It's **not an antimicrobial or antispasmodic**, and should not replace diagnostics to identify underlying causes :contentReference[oaicite:4]{index=4}.

💊 Dosage & Administration

• Route: Intravenous only.
• Dose: 30 mg/kg IV every 12 hours.
• Duration: Up to 3 days, based on fever recurrence and clinical response :contentReference[oaicite:5]{index=5}.
• Single-field study showed **74.8% success** (≥2°F drop in 6 hours) vs 20.6% in controls :contentReference[oaicite:6]{index=6}.
• Maximum dosing frequency: **twice daily (q12h)**; dosing sooner increases coagulopathy risk :contentReference[oaicite:7]{index=7}.

⚠️ Contraindications & Precautions

Do not use Zimeta® in:

• Horses with **hypersensitivity to dipyrone** or related NSAIDs :contentReference[oaicite:8]{index=8}.
• Horses younger than 3 years, or pregnant/lactating/breeding horses—safety not established :contentReference[oaicite:9]{index=9}.
• Horses intended for food production—**not allowed** in food animals :contentReference[oaicite:10]{index=10}.

Use caution with:

• Horses at risk for bleeding, coagulopathy, ulcers, or renal/hepatic impairment—can prolong PT/PTT and cause platelet dysfunction :contentReference[oaicite:11]{index=11}.
• Concurrent NSAIDs or corticosteroids—avoid due to higher risk of GI or renal damage :contentReference[oaicite:12]{index=12}.

🛡️ Safety & Field Study Observations

Field trials (138 horses) indicate Zimeta® is:

• **Effective** in reducing fever within 6 hours in ~75% of cases :contentReference[oaicite:13]{index=13}.
• **Well tolerated** for up to 3 days at 30 mg/kg BID :contentReference[oaicite:14]{index=14}.
• Safe compared to triple-daily dosing, which showed no additional benefit but increased risk :contentReference[oaicite:15]{index=15}.

📈 Adverse Effects & Monitoring

Monitor for these common side effects:

• GI: diarrhea, colic, gastric ulcers :contentReference[oaicite:16]{index=16}.
• Hepatic: elevated SDH levels noted in 5% of cases :contentReference[oaicite:17]{index=17}.
• Coagulopathy: prolonged aPTT or PT, bleeding, nasal or GI hemorrhage :contentReference[oaicite:18]{index=18}.
• Renal effects: increased creatinine in ~1% of horses :contentReference[oaicite:19]{index=19}.
• Injection reactions: occasional site inflammation :contentReference[oaicite:20]{index=20}.

If adverse signs occur, discontinue use and seek veterinary care.

🔬 Laboratory Monitoring Recommendations

• Baseline CBC, biochemistry (renal & hepatic enzymes, albumin), clotting times before use.
• Recheck within 24 hours if therapy continues; daily monitoring if prolonged.
• Cease therapy if significant coagulopathy, GI ulceration, or organ dysfunction arise.

🏥 Handling & Human Safety

• Wear gloves and avoid skin contact—in humans, dipyrone can cause **agranulocytosis** :contentReference[oaicite:21]{index=21}.
• Be cautious to prevent accidental self-injection—seek medical care if exposure occurs :contentReference[oaicite:22]{index=22}.

🌡️ Storage & Shelf Life

• Store at 20–25 °C (68–77 °F), excursions allowed 15–30 °C; protect from light :contentReference[oaicite:23]{index=23}.
• Use multi-dose vial within 30 days of first puncture :contentReference[oaicite:24]{index=24}.

📋 Quick Reference Table

✅ Clinical Management Tips

• Always perform a full exam and diagnostics before using Zimeta®.
• Use conservative dosing and re-evaluate daily.
• Do not combine with other NSAIDs or corticosteroids.
• Discontinue and reassess if adverse effects appear.
• The drug controls fever—it does not treat underlying infection or inflammation.

📲 Need Support?

For help with dosing protocols, monitoring guidelines, or client education resources, our **Ask A Vet** team is ready. Download the Ask A Vet app for 24/7 veterinary advice, medication trackers, and clinical toolkits tailored to your practice. 🌟