Vet Guide to Exercise-Induced Collapse (EIC) in Labrador Retrievers 2025 🐶🏃♂️💥

By Dr. Duncan Houston BVSc

Exercise-Induced Collapse (EIC) is a genetic neuromuscular disorder that affects primarily Labrador Retrievers, causing muscle weakness and potential collapse after vigorous activity. In this 2025 guide, I'll explain the genetics, clinical signs, diagnostic process, management strategies, and breeding recommendations to keep your lab safe and active. 💡

📍 What is EIC?

EIC is an inherited condition resulting from a mutation in the DNM1 gene, affecting nerve function during high-intensity exercise. Affected dogs seem normal at rest but develop collapse 5–20 minutes into vigorous activity, often recovering within 5–25 minutes.

⚠️ Who is at Risk?

• Occurs mainly in Labrador Retrievers — black, yellow, or chocolate.
• Typically starts between 5 months and 3 years of age, especially in athletic, field-bred labs.
• Autosomal recessive inheritance: only dogs with two copies of the gene mutation (E/E) are affected. Carriers (N/E) are asymptomatic but can pass the gene.

📝 Key Symptoms

• Hind limb weakness, wide-based gait, and dragging of rear legs.
• Collapse during exercise, with front limbs often stiff.
• Increased heart rate, elevated body temperature, and disorientation in severe cases.
• No pain; dogs typically recover full strength within half an hour.
• Rarely: seizures or fatal episodes if exercise continues.

🔬 Diagnosis & Testing

• History and clinical signs guide suspicion; normal bloodwork rules out other causes.
• Definitive genetic test for DNM1 mutation via cheek swab.

❗ Management & Lifestyle Tips

• Avoid strenuous exercise and high excitement activities such as retrieving games or intense runs, and in hot weather.
• Introduce low-impact activities: short walks, swimming, and mentally enriching games.
• Cool your dog during activity, offer water, and stop immediately at the first sign of weakness.
• No current medical or surgical cure; phenobarbital may help some dogs stay calm and reduce episodes.

👨👩👧 Breeding & Genetic Recommendations

• Genetic testing prior to breeding is essential.
• Do not breed affected (E/E) or carrier (N/E) dogs together. Breeding a carrier to a clear (N/N) dog is acceptable.
• Testing has reduced disease prevalence; just ~6–8% of Labradors are affected and 30–40% are carriers.

📊 Quick Reference Table

✅ Vet Tips by Dr Duncan Houston BVSc

• 🎯 Suspect EIC in young, athletic labs that collapse after intense play.
• 🔬 Use genetic testing for a definitive diagnosis and to guide breeding decisions.
• 💡 Prevent episodes by avoiding known triggers and monitoring activity.
• 📆 Annual check-ups and consultation on safe exercise routines.

Concerned your Lab shows signs of EIC? Reach out via the AskAVet.com app for rapid guidance.🐾❤️