📚 What Is Shope Papilloma Virus?

Shope papilloma virus (also known as cottontail rabbit papilloma virus or Kappapapillomavirus 2) is a DNA virus in the family Papillomaviridae that infects rabbits, causing keratinous wart-like growths—often horn-like—around the head and ears :contentReference[oaicite:3]{index=3}.

🌟 Natural History & Significance

First identified in wild cottontail rabbits in the 1930s, this virus was discovered by Richard E. Shope, marking one of the earliest known cases of viral-induced tumors in mammals :contentReference[oaicite:4]{index=4}. These growths sometimes inspired folklore creatures like the "Jackalope" due to their horn-like appearance :contentReference[oaicite:5]{index=5}.

🧬 How It Spreads and Which Species Are Affected

• Spread primarily via biting insects—ticks, mosquitoes—and direct contact :contentReference[oaicite:6]{index=6}.
• Natural hosts include cottontails and jackrabbits; domestic and European rabbits are incidental hosts and may develop warts, but usually don’t spread the virus onward :contentReference[oaicite:7]{index=7}.

⚠️ Clinical Signs to Recognize

• Raised, rough papillomatous lesions on the skin—commonly ears, eyelids, muzzle, neck :contentReference[oaicite:8]{index=8}.
• Horn-like protrusions—keratinous masses that can grow large enough to impair eating or vision :contentReference[oaicite:9]{index=9}.
• Possible progression to squamous cell carcinoma—especially in domestic rabbits (~25–75% risk) :contentReference[oaicite:10]{index=10}.

🔬 Diagnosing Shope Papillomatosis

• Clinical observation of hallmark warty lesions ​
• Histopathology of biopsied tissue confirms papilloma and checks for malignant changes :contentReference[oaicite:11]{index=11}.
• Molecular testing for viral DNA not usually needed in clinical practice but used in research :contentReference[oaicite:12]{index=12}.

💉 Treatment Options

1. Surgical Removal

Surgical excision is the most effective method to eliminate warts and reduce cancer risk. Follow-up exams are essential for early detection of recurrence :contentReference[oaicite:13]{index=13}.

2. Monitoring & Conservative Management

• Some lesions may regress spontaneously.
• Regular veterinary check-ups monitor lesion progression or malignant transformation.

3. No Available Vaccine

No vaccine is currently available for Shope papilloma virus. Research focuses on viral oncoproteins E6/E7, similar to early HPV vaccine development :contentReference[oaicite:14]{index=14}.

📈 Prognosis & Follow-Up

• Benign papillomas often have an excellent outcome after removal.
• However, these lesions can progress to carcinoma in up to 75% of domestic rabbits :contentReference[oaicite:15]{index=15}.
• Regular re-checks ensure recurrence is caught early, improving prognosis.

🏡 Home Care & Management Tips

• Isolate affected rabbits from wild animals and insect vectors.
• Clean and disinfect enclosures regularly.
• Prevent rabbits from scratching lesions to reduce infection risk.
• Supplement diet, grooming, and pain relief as needed after surgical removal.

🛡️ Prevention Strategies

• Protect rabbits from insect bites—use mosquito screens and tick control.
• Limit wild rabbit access to domestic rabbit areas and hay sources.
• Quarantine newcomers to household rabbits until lesions are ruled out.

🧠 Vet Tips for 2025

• Investigate suspicious horned growths on heads or ears—Shope papillomavirus is rare but serious.
• Recommend biopsy to differentiate between benign papillomas and carcinoma.
• Advise clients about insect-borne risk and preventive housing measures.
• Encourage research collaborations for improved antiviral vaccines and lesion monitoring.

🔚 Final Takeaway

🦠 Shope papilloma virus is an unusual but clinically relevant infection in rabbits that causes striking wart-like lesions and may progress to carcinoma. With prompt diagnosis, surgical removal, and preventive measures, most affected rabbits live well. In 2025, alert veterinary attention and owner education can keep these rare lesions from becoming serious. 🐇❤️

🌟 Partner Services

• Ask A Vet: Live access to veterinary specialists for diagnosis guidance, biopsy planning, surgical tips, and follow-up care.
• Woopf: Insect protection kits, secure bedding, and post-surgical recovery packs to support healing.
• Purrz: Wound cleansing supplies, herbal antiviral sprays, and growth monitoring supplements.