Vet Guide to Deracoxib (Deramaxx®) in 2025 🐾

Hi, I’m Dr Duncan Houston, BVSc—founder of Ask A Vet. This comprehensive 2025 guide covers **deracoxib**, sold as Deramaxx®, a COX‑2 selective NSAID prescribed exclusively for dogs. I’ll walk you through how it works, when it's used, accurate dosing, safety checks, and long-term considerations to ensure your pup’s comfort and wellbeing. 🐶💊

📘 What Is Deracoxib?

Deracoxib is a selective COX‑2 NSAID used in dogs to reduce pain and inflammation following orthopedic or dental surgery, or due to osteoarthritis and other painful conditions :contentReference[oaicite:3]{index=3}.

✅ Primary Uses

• **Post-surgical pain relief:** orthopedic, general, and dental procedures :contentReference[oaicite:4]{index=4}.
• **Osteoarthritis control:** reduces inflammation and improves mobility :contentReference[oaicite:5]{index=5}.
• **Fever or inflammation from other conditions:** used off-label under veterinary supervision :contentReference[oaicite:6]{index=6}.

📐 How It Works

Deracoxib inhibits COX‑2 enzymes that produce inflammatory prostaglandins, helping control pain and inflammation while sparing COX‑1 functions important for gut and kidney health—though higher doses may affect COX‑1 as well :contentReference[oaicite:7]{index=7}.

📋 Administration & Dosing

• Administered once daily as beef‑flavored chewable tablet, with food to reduce GI upset :contentReference[oaicite:8]{index=8}.
• Dosing varies by condition:
  • **Post-op orthopedic:** 1.4–1.8 mg/lb daily for up to 7 days :contentReference[oaicite:9]{index=9}.
  • **Dental surgery:** 0.45–0.91 mg/lb daily for 3 days :contentReference[oaicite:10]{index=10}.
  • **Osteoarthritis:** 0.45–0.91 mg/lb daily, lowest effective dose :contentReference[oaicite:11]{index=11}.
• If a dose is missed, give it when remembered unless it's near the next dose; do not double up or switch NSAIDs without a 7‑day washout :contentReference[oaicite:12]{index=12}.

⚠️ Potential Side Effects

Side effects stem from reduced protective prostaglandins in the GI tract, kidneys, or liver :contentReference[oaicite:13]{index=13}:

• Mild: vomiting, diarrhea, decreased appetite, lethargy :contentReference[oaicite:14]{index=14}.
• Serious: ulcers, kidney or liver injury, jaundice, seizures, incoordination, bleeding, tachycardia :contentReference[oaicite:15]{index=15}.

📛 Contraindications & Precautions

• Not recommended for cats—format and doses untested :contentReference[oaicite:16]{index=16}.
• Avoid in dogs with:
  • GI ulcers, liver/kidney disease, dehydration, bleeding disorders, heart disease, or protein loss :contentReference[oaicite:17]{index=17}.
  • Sulfonamide hypersensitivity :contentReference[oaicite:18]{index=18}.
  • Concurrent NSAIDs, corticosteroids, diuretics, ACE inhibitors, or cyclosporine—risk of serious interactions :contentReference[oaicite:19]{index=19}.
  • Breeding, pregnant, nursing dogs—safety not established :contentReference[oaicite:20]{index=20}.

🩺 Monitoring & Veterinary Follow‑Up

• Baseline CBC, renal and liver panels, urinalysis before extended use; repeat after 1–2 weeks, then every 6–12 months :contentReference[oaicite:21]{index=21}.
• Watch daily for appetite, stool, energy, thirst/urination; stop medication and call vet if severe signs appear.

🏡 Practical Case Examples

🐶 Post-Op Orthopedic Dog

• Started on 1.6 mg/lb Deramaxx with food once daily for 7 days. Pain improved within 1–2 hours; no GI upset observed.

🐶 Senior Dog with Arthritis

• Started on 0.6 mg/lb daily after bloodwork showed normal kidney/liver values. Client reported improved mobility; rechecked labs at 2 weeks and then quarterly.

❓ FAQs

Can I give my dog human NSAIDs like ibuprofen?

No—human NSAIDs are toxic for dogs; Deramaxx is veterinary-specific and safer when prescribed :contentReference[oaicite:22]{index=22}.

Can Deramaxx and Rimadyl be used together?

Never—combining NSAIDs increases the risk of life-threatening side effects. If switching, allow a 7‑day washout :contentReference[oaicite:23]{index=23}.

Is it safe long-term for arthritis?

Yes—under veterinary monitoring. Use the lowest effective dose and regular labs to minimize organ risk :contentReference[oaicite:24]{index=24}.

📌 Final Takeaways

• Deramaxx® is a COX‑2 selective NSAID for canine post-surgical and arthritis pain relief.
• Use lowest effective dose based on condition; typical ranges: 0.45–1.8 mg/lb daily.
• Monitor for GI, kidney, liver side effects with regular labwork and observe for warning signs.
• Avoid in high-risk dogs and dangerous drug combinations; consult vet first.
• Well-managed NSAID use greatly enhances comfort and quality of life in dogs when used responsibly.

Want help managing your dog’s pain with Deramaxx® safely? Download the Ask A Vet app for dosing reminders, lab-tracking tools, side‑effect alerts, and 24/7 vet support—ensuring your pup stays happy, healthy, and pain‑free. 🐾❤️