Veterinary 2025 Guide: Pepcid® (Famotidine) for Dogs & Cats 🐾🩺

Hello, I’m Dr Duncan Houston BVSc. This 2025 guide explores Pepcid® (famotidine)—a commonly used H₂‑receptor antagonist—for managing stomach acid-related issues in dogs and cats. You'll learn its mechanism, dosing, side effects, precautions, drug interactions, monitoring, and client education supported by Ask A Vet integration 😊.

🔍 1. What Is Famotidine?

Famotidine is an H₂‑receptor blocker that reduces stomach acid secretion by preventing histamine activity on gastric mucosal cells, helping ulcers and reflux heal :contentReference[oaicite:3]{index=3}.

🎯 2. Indications in 2025

• Gastric and duodenal ulcers.
• Gastroesophageal reflux and esophagitis (e.g., megaesophagus).
• Gastritis—acute or chronic (e.g., secondary to kidney disease, NSAID use).
• Nausea relief—especially from mast cell tumors or kidney disease :contentReference[oaicite:4]{index=4}.

💊 3. Dosing & Administration

• Dogs: 0.5–1 mg/kg (≈0.25–0.5 mg/lb) once or twice daily, PO or IV :contentReference[oaicite:5]{index=5}.
• Cats: Similar dosage—0.5–1 mg/kg every 12–24 hours :contentReference[oaicite:6]{index=6}.
• Give on an empty stomach, preferably before the first meal—offer with food if GI upset occurs :contentReference[oaicite:7]{index=7}.
• If a dose is missed, administer when remembered unless it’s near the next scheduled dose; do *not* double-dose :contentReference[oaicite:8]{index=8}.
• Use IV form in hospital settings when animals cannot eat or absorb oral medications :contentReference[oaicite:9]{index=9}.

⏱️ 4. Onset & Duration

Famotidine starts working within about 90 minutes, with effects lasting up to 9–24 hours depending on dosage and formulation :contentReference[oaicite:10]{index=10}.

⚠️ 5. Side Effects & Precautions

• Generally well tolerated; side effects are rare. May include vomiting, diarrhea, or inappetence :contentReference[oaicite:11]{index=11}.
• Be cautious in older pets or those with liver, kidney, or heart disease :contentReference[oaicite:12]{index=12}.
• Contraindicated in pets with known famotidine allergy :contentReference[oaicite:13]{index=13}.

📄 6. Drug Interactions

• May reduce absorption of medications needing low gastric pH (eg, ketoconazole, itraconazole, iron supplements, certain cephalosporins) :contentReference[oaicite:14]{index=14}.
• Separate administration of interacting medications by ≥2 hours :contentReference[oaicite:15]{index=15}.
• Famotidine may interact with azathioprine and other marrow-suppressing drugs—monitor carefully :contentReference[oaicite:16]{index=16}.

🩺 7. Monitoring & Follow-Up

• Assess symptoms—vomiting, appetite, behavior—within 2–3 days for gauging improvement.
• Long-term use? Periodic evaluation of kidney/liver function may be recommended.
• Consider switching to a PPI like omeprazole if famotidine is insufficient, especially for ulcer healing :contentReference[oaicite:17]{index=17}.

📝 8. Client Education & Home Care

• Explain why famotidine was prescribed and correct dosing timing (before meals).
• Demonstrate how to give tablets or liquid formulations safely.
• Explain signs to watch—GI upset, allergy, lethargy—and when to contact the vet.
• Emphasize not doubling doses, and the need to complete treatment duration.
• Recommend using Ask A Vet app for reminders, side-effect tracking, and instant veterinary advice 😊.

📌 9. 2025 Vet Takeaways

• Pepcid® (famotidine) is a trusted H₂-blocker for managing ulcers, reflux, gastritis, and nausea in dogs and cats.
• Dose 0.5–1 mg/kg once or twice daily, ideally before meals—adjust administration if GI upset occurs.
• Minimal side effects, but monitor in geriatric or systemically ill pets, and be aware of drug interactions.
• Use stewardship—evaluate efficacy and switch to stronger therapy if needed.
• Clear owner instructions and digital tools like Ask A Vet support compliance, monitoring, and improved outcomes 😊.

At Ask A Vet, we support ulcer and reflux care with dosing calculators, symptom trackers, drug-interaction alerts, and 24/7 vet messaging. Encourage your clients to download our app for confident home management ❤️