Veterinary 2025 Guide: Pepto‑Bismol® (Bismuth Subsalicylate) for Canine GI Upset 🐶🩺

Hello, I’m Dr Duncan Houston BVSc. In this 2025 guide, we explore **Pepto‑Bismol®**—an over-the-counter bismuth subsalicylate prep commonly used in dogs (but **not** recommended for cats). Covering how it works, dosing guidance, risks (including GI bleeding and black stool), contraindications, and owner advice—with helpful support via Ask A Vet 😊.

🔍 1. What Is Bismuth Subsalicylate?

Bismuth subsalicylate combines antacid, anti-inflammatory, mild-antibiotic, and intestinal-coating properties—making it useful for treating diarrhea, nausea, and upset stomach in dogs. It’s **unsafe for cats** due to salicylate toxicity :contentReference[oaicite:3]{index=3}.

🎯 2. Indications in Dogs

• Short-term relief of mild diarrhea or anal upset with normal activity/appetite :contentReference[oaicite:4]{index=4}.
• May be appropriate during travel or stress-induced GI distress—only under vet direction :contentReference[oaicite:5]{index=5}.

💧 3. Dosing & Administration

• **Typical dose:** 1 teaspoon (≈ 5 mL) per 10 lb of body weight every 6–8 hours, not exceeding 2–3 doses or 24 h :contentReference[oaicite:6]{index=6}.
• Merck dosage reference: 1–3 mL/kg PO every 24 h in divided doses :contentReference[oaicite:7]{index=7}.
• Administer orally via syringe or dropper; dose may be mixed into food if needed.
• If a dose is missed and it’s >2 hrs until the next, give it; otherwise skip–do **not** double dose.

⏱️ 4. Onset & Duration

Effects start within 1–2 days, with benefits seen in stool consistency and appetite—discontinue if no improvement or symptoms worsen after 24 h :contentReference[oaicite:8]{index=8}.

⚠️ 5. Side Effects & Safety Concerns

• Common: temporary constipation and dark black or greenish-black stool (harmless but may mask bleeding) :contentReference[oaicite:9]{index=9}.
• Serious: risk of GI ulcers or bleeding—avoid in pets with GI disease, clotting disorders, or on NSAIDs/aspirin :contentReference[oaicite:10]{index=10}.
• Overdose signs: vomiting, diarrhea (possibly blood), dehydration, unsteadiness, lethargy—seek immediate vet care :contentReference[oaicite:11]{index=11}.

🚫 6. Contraindications & Precautions

• **Cats:** absolutely avoid—unsafe even under vet care :contentReference[oaicite:12]{index=12}.
• Puppies under 12 weeks, pregnant/nursing dogs, or those on NSAIDs should **not** receive it without vet approval :contentReference[oaicite:13]{index=13}.
• Avoid if suspected GI ulcer, bleeding disorders, or concurrent salicylate/aspirin use :contentReference[oaicite:14]{index=14}.

📋 7. Drug Interactions

• Can reduce absorption of tetracyclines or ciprofloxacin—space dosing by ≥ 2 hours :contentReference[oaicite:15]{index=15}.
• Combining with anticoagulants increases bleeding risk :contentReference[oaicite:16]{index=16}.

🩺 8. Monitoring & When to Reassess

• Monitor stool for consistency and color; look out for black tarry stool :contentReference[oaicite:17]{index=17}.
• Reevaluate if symptoms persist >24 hrs, reappear, or systemic signs (vomiting, lethargy) occur.
• Caution with dehydration; if ongoing, consider fluid therapy.

📝 9. Client Education & Home Instructions

• Explain **short-term** use only—1–2 doses maximum, and only for mild GI upset.
• Highlight black stool and caution masking bleeding; report any dark/red urine/stool.
• Demonstrate measuring with syringe and timing doses.
• Warn against use in cats or dogs on NSAIDs/with bleeding disorders or known ulcers.
• Recommend using Ask A Vet app for dose reminders, monitoring stool, and quick veterinary advice 😊.

📌 10. 2025 Vet Takeaways

• Pepto‑Bismol® can be a useful short-term remedy for mildly upset dogs—but **never use in cats**.
• Dose at 5 mL per 10 lb every 6–8 hrs, max 2–3 doses or 24 h.
• Monitor for black stool, constipation, or bleeding—discontinue and vet-check as needed.
• Contraindicated in GI ulcers, clotting issues, NSAIDs use, young or pregnant animals.
• Educate owners thoroughly and support them with digital tools for safe home use 😊.

At Ask A Vet, we offer dosing calculators, symptom trackers, alert reminders, and 24/7 veterinary messaging to ensure safe, effective GI care. Encourage owners to download our app for confident, anxiety-free support ❤️