Veterinary 2025 Guide: Posatex® Otic Suspension for Canine (and Feline) Ear Infections 🐶🩺

Hello, I’m Dr Duncan Houston BVSc. This 2025 guide covers Posatex® Otic Suspension—a powerful triple‑action antimicrobial for stubborn or recurrent otitis externa in dogs, used extra‑label in cats under supervision. It contains a fluoroquinolone antibiotic (orbifloxacin), a corticosteroid (mometasone furoate), and a broad‑spectrum antifungal (posaconazole). You'll learn indications, dosing, safety concerns, contraindications, monitoring strategies, and client support via Ask A Vet 😊.

🔍 1. What Is Posatex®?

Posatex® is an otic suspension combining:
• Orbifloxacin (10 mg/g): fluoroquinolone antibiotic targeting Pseudomonas, Staph, Enterococcus
• Mometasone furoate (1 mg/g): potent anti‑inflammatory corticosteroid
• Posaconazole (1 mg/g): broad‑spectrum antifungal effective against Malassezia :contentReference[oaicite:3]{index=3}.

🎯 2. Indications & Use

• Dogs: FDA‑approved for otitis externa with yeast and/or bacteria :contentReference[oaicite:4]{index=4}.
• Cats: Extra‑label use allowed under veterinary oversight for similar infections :contentReference[oaicite:5]{index=5}.
• Typically reserved for chronic or resistant cases where prior treatments failed :contentReference[oaicite:6]{index=6}.

💧 3. Dosing & Administration

• Shake well before use. Clean and dry the ear canal thoroughly, trimming excess hair :contentReference[oaicite:7]{index=7}.
• Dogs < 30 lb: 4 drops/ear once daily for 7 days; ≥ 30 lb: 8 drops/ear once daily for 7 days :contentReference[oaicite:8]{index=8}.
• Massage gently after instilling to enhance dispersion :contentReference[oaicite:9]{index=9}.
• Repeat for 7 consecutive days; do not exceed this duration unless advised :contentReference[oaicite:10]{index=10}.

⚠️ 4. Safety & Adverse Effects

• Transient hearing loss: Rare but reversible—stop use if observed :contentReference[oaicite:11]{index=11}.
• Adrenocortical suppression: High–dose studies show mild ACTH suppression, reversible post-treatment :contentReference[oaicite:12]{index=12}.
• Local irritation: Mild redness or swelling possible :contentReference[oaicite:13]{index=13}.
• Cartilage caution: Avoid use in puppies <6‑12 mo due to fluoroquinolone risk :contentReference[oaicite:14]{index=14}.

🚫 5. Contraindications & Precautions

• Do not use if the eardrum is ruptured—risk of inner ear damage :contentReference[oaicite:15]{index=15}.
• Avoid in animals with known hypersensitivity to quinolones, corticosteroids, or azoles :contentReference[oaicite:16]{index=16}.
• Not evaluated for pregnant, breeding, or lactating animals—avoid use :contentReference[oaicite:17]{index=17}.
• Repeated use may lead to adrenal suppression—monitor if re-treating :contentReference[oaicite:18]{index=18}.

🩺 6. Monitoring & Follow‑Up

• Expect improvement in irritation, odor, and discharge during or shortly after the 7‑day course.
• Re-evaluate if no improvement by day 4; consider culture or alternative therapy.
• Watch for signs of hearing loss, vestibular dysfunction or ear pain—flush ear and discontinue if present :contentReference[oaicite:19]{index=19}.
• For recurrent cases, assess adrenal function before re-treatment.

📝 7. Client Education & Home Care

• Demonstrate how to clean the ear canal and administer drops properly.
• Emphasize the importance of shaking the bottle, massage after dosing, and adhering to the 7‑day treatment.
• Explain possible transient hearing loss and when it requires veterinary attention.
• Inform that fluoroquinolones can affect immature cartilage—avoid use in puppies unless essential.
• Recommend using the Ask A Vet app for dose reminders, side-effect alerts, and vet messaging 😊.

📌 8. 2025 Vet Takeaways

• Posatex® is a potent once‑daily, triple‑action otic suspension ideal for tough otitis externa in dogs—and used extra‑label in cats.
• Use for 7 days: 4–8 drops per ear based on weight, after cleaning and drying.
• Ensure intact eardrums, monitor for hearing/vestibular signs; avoid in pregnant, lactating, or young puppies.
• Limit repeat use due to adrenal suppression risk; monitor adrenal function.
• Clear owner guidance supported by digital tools like Ask A Vet ensures safety, compliance, and treatment success 😊.

At Ask A Vet, our veterinary toolkit includes dosing calculators, treatment reminders, symptom trackers, and 24/7 messaging to support safe, effective ear infection care. Encourage clients to download our app for confident and connected home care ❤️