Comprehensive Vet Guide 2025: Temaril‑P for Dogs & Cats 🐾💊

Written by Dr Duncan Houston, BVSc — professional vet & founder of Ask A Vet 👨‍⚕️🐾

This extensive guide explores Temaril‑P, a combination of trimeprazine and prednisolone, used in 2025 to manage itching and coughing in dogs—and occasionally off‑label in cats. Learn about how it works, dosing, side effects, tapering, monitoring, and how Ask A Vet, Woopf & Purrz support you every step of the way. 🩺📘

1. What Is Temaril‑P & How It Works?

Temaril‑P is an FDA‑approved veterinary medication combining an antihistamine (trimeprazine) with a corticosteroid (prednisolone) to reduce allergic inflammation and suppress coughing. Trimeprazine blocks histamine effects, easing itch and cough, while prednisolone reduces inflammatory processes—allowing lower steroid doses and reducing side effects compared to steroids alone :contentReference[oaicite:3]{index=3}.

2. Approved & Off‑Label Uses

• FDA‑approved in dogs: to relieve pruritus (itchiness) from allergies and to treat coughing associated with inflammatory airway conditions or kennel cough :contentReference[oaicite:4]{index=4}.
• Off‑label use in cats: occasionally prescribed for severe allergic dermatitis or persistent cough under veterinary guidance :contentReference[oaicite:5]{index=5}.

3. Dosage & Administration

Initial dosing for dogs:

• Up to 10 lb: ½ tablet every 12 hrs
• 11–20 lb: 1 tablet every 12 hrs
• 21–40 lb: 2 tablets every 12 hrs
• >40 lb: 3 tablets every 12 hrs

After 4 days, taper gradually to the minimum effective dose—often ½ to 1 tablet daily :contentReference[oaicite:6]{index=6}.

Administration: Offer with or without food. With food helps reduce stomach upset. Always ensure fresh water is available :contentReference[oaicite:7]{index=7}.

Missed dose? Give it when you remember, unless it’s almost time for the next dose—don’t double up :contentReference[oaicite:8]{index=8}.

4. Side Effects & Risks

Common side effects include:

• Sleepiness or sedation, muscle tremors or stiffness :contentReference[oaicite:9]{index=9}.
• Increased thirst, urination, appetite; weight gain; pot‑bellied appearance :contentReference[oaicite:10]{index=10}.
• Vomiting, diarrhea, stomach upset; potential delayed wound healing, suppressed immunity :contentReference[oaicite:11]{index=11}.

Serious warning signs:

• Allergic reaction—swelling, difficulty breathing, hives :contentReference[oaicite:12]{index=12}.
• Hypotension, extreme lethargy, behavioral changes, hallucinations, or seizures :contentReference[oaicite:13]{index=13}.

If any serious signs occur—stop the medication and contact your vet immediately.

5. Tapering & Long‑Term Use

Temaril‑P is best used short‑term. For longer courses, taper slowly under veterinary supervision. Suddenly stopping can cause steroid withdrawal (lethargy, vomiting, weakness) :contentReference[oaicite:14]{index=14}. Chronic steroid use can increase Cushing’s risk (pot‑belly, hair loss, skin fragility) :contentReference[oaicite:15]{index=15}.

6. Drug Interactions & Contraindications

• Avoid combining with ACE inhibitors, NSAIDs, antibiotics (like rifampin), cyclosporine, digoxin, insulin, and certain antiepileptics—these can intensify side effects or reduce efficacy :contentReference[oaicite:16]{index=16}.
• Do not use in pets with untreated Cushing’s disease, GI ulcers, severe infections, diabetes, heart failure, liver or kidney dysfunction, pregnancy, or young animals <6 months old :contentReference[oaicite:17]{index=17}.

7. Monitoring & Safety

• Monitor hydration, appetite, energy, urination, and weight.
• For prolonged use, monitor blood pressure, bloodwork, adrenal function, liver/kidney health and screen for infections.
• Reassess regularly to ensure you're using the lowest effective dose.

8. Storage & Handling

• Store in a cool, dry place <77 °F (25 °C), sealed and away from light—a secured location is essential :contentReference[oaicite:18]{index=18}.
• Keep out of reach of children and other pets.

9. Role of Ask A Vet, Woopf & Purrz

• Ask A Vet: On‑demand dosing advice, side‑effect reviews, tapering plans and lab interpretation.
• Woopf: Timely pill reminders, dosing logs and taper schedules ensure compliance.
• Purrz: Track itch intensity, coughing frequency, vitals, hydration and appetite to share with your vet.

10. Pet Owner Experiences

Many owners report Temaril‑P brings fast itch relief and calmer cough within a day. Keeping track with tools like Woopf helps maintain the right dose and ensures smoother creative healing.

11. FAQs

🐾 Can I give Temaril‑P daily indefinitely?

No—it's designed for short‑term relief. For longer use, taper and switch to safer, long-term strategies under vet guidance.

🐾 What if my pet vomits after taking it?

Try with food on the next dose. If vomiting persists, contact your vet for possible dose adjustment or alternative medicine.

🐾 Is Temaril‑P safe for cats?

It's off‑label in cats—use only under veterinary guidance due to dosing differences and sensitivity risks.

🐾 Can Temaril‑P affect behavior?

Yes—steroids may cause restlessness, aggression, or unusual vocalization. Monitor and consult your vet if behavior changes are concerning.

12. Summary Table

13. Final Thoughts from Dr Duncan

Temaril‑P can offer quick and effective relief from discomfort—but use only as directed, for the shortest duration needed. Careful tapering, thorough monitoring, and support from Ask A Vet, Woopf & Purrz help ensure your pet stays safe, comfortable, and healthy. Always check with your vet before starting or stopping this medication—your companion’s well‑being deserves nothing less. 💗🐾

For dosing reminders, side‑effect reviews, and expert tapering support, visit AskAVet.com and download the Ask A Vet app. Your pet’s comfort matters every day—24/7. 🐶📱🐱