Vet Guide to Galliprant® (Grapiprant) in 2025 🐕‍🦺

Hello, I’m Dr Duncan Houston, BVSc, founder of Ask A Vet. This comprehensive 2025 guide explores **Galliprant® (grapiprant)**—a novel NSAID designed to relieve pain and inflammation in dogs with osteoarthritis by blocking the EP4 receptor. We'll cover how it works, dosing, efficacy, safety profile, monitoring, contraindications, and practical guidance for using it effectively over the long term. 🐾

📘 What Is Galliprant®?

Galliprant® (active: grapiprant) is a novel **prostaglandin E₂ EP4 receptor antagonist**, offering a targeted NSAID approach. Unlike traditional NSAIDs that inhibit COX enzymes (COX‑1/COX‑2), it prevents PGE₂ from binding to EP4 receptors—reducing pain and inflammation while preserving gastrointestinal, renal, and clotting functions :contentReference[oaicite:3]{index=3}.

✅ Approved Use

• FDA-approved for managing **pain and inflammation** associated with **osteoarthritis in dogs** :contentReference[oaicite:4]{index=4}.
• Not for use in cats or off-label in other species :contentReference[oaicite:5]{index=5}.

📐 How It Works

By selectively antagonizing the EP4 receptor, Galliprant targets the key mediator of arthritic pain and inflammation without disrupting protective prostanoids—resulting in fewer side-effects compared to classical NSAIDs :contentReference[oaicite:6]{index=6}.

📐 Dosage & Administration

• Standard dose: **2 mg/kg** once daily, with or without food (best absorbed on an empty stomach; if GI upset, give with food) :contentReference[oaicite:7]{index=7}.
• Available in flavored pork-based chewable tablets: 20, 60, and 100 mg sizes :contentReference[oaicite:8]{index=8}.
• Missed dose? Give as soon as remembered unless it's time for the next dose. **Do not double** doses in one day :contentReference[oaicite:9]{index=9}.
• Onset of action within **1–2 hours**, with daily dosing maintaining consistent relief :contentReference[oaicite:10]{index=10}.

🩺 Efficacy Compared to Other NSAIDs

Clinical studies show grapiprant provides meaningful pain relief in canine OA. While some research indicates COX‑2 inhibitors like firocoxib may offer stronger relief in acute pain models, grapiprant remains effective for chronic arthritis with a favorable safety profile :contentReference[oaicite:11]{index=11}.

⚕️ Safety & Side‑Effects

Common, mild:

• Gastrointestinal upset: vomiting, diarrhea, reduced appetite or soft stools (occasionally mucous or blood) :contentReference[oaicite:12]{index=12}.
• Mild drops in serum albumin or total protein – usually not clinically significant :contentReference[oaicite:13]{index=13}.

Less common/serious:

• Allergic reactions—hives, facial swelling, respiratory distress—rare but require immediate care :contentReference[oaicite:14]{index=14}.
• Theoretical kidney or GI risks remain—but data so far shows reduced adverse events compared to COX-drug classes :contentReference[oaicite:15]{index=15}.

🚫 Contraindications & Precautions

• Not approved for <9 months old, <3.6 kg (8 lb), pregnant/nursing, breeding dogs, or those with heart disease :contentReference[oaicite:16]{index=16}.
• Use cautiously in dogs with MDR1 (ABCB1) gene mutation—dose adjustment may be needed :contentReference[oaicite:17]{index=17}.
• Combining with other NSAIDs or corticosteroids increases risk; avoid concurrent use :contentReference[oaicite:18]{index=18}.
• Monitor kidney/liver function in aged or systemically ill dogs :contentReference[oaicite:19]{index=19}.

🔗 Drug Interactions & Monitoring

• Interacts with NSAIDs (e.g., carprofen, firocoxib), corticosteroids, and blood pressure drugs—inform your vet of all medications :contentReference[oaicite:20]{index=20}.
• No regular lab monitoring usually needed—but periodic bloodwork is recommended, especially for long-term use :contentReference[oaicite:21]{index=21}.

🏡 Practical Tips

• Give on empty stomach for best absorption; if upset occurs, mix with a small treat or food.
• Use lowest effective dose and assess benefits every 4–8 weeks via mobility, activity, and pain scoring.
• Rotate dosing times (morning vs. evening) to match your pet’s routine and vet visits.

📆 Long‑Term Use

Galliprant® has been shown to be safe over **months or even years** of daily use—studies using up to 25× dose for 9 months in healthy dogs found only mild GI side-effects :contentReference[oaicite:22]{index=22}. However, this doesn’t replace veterinary monitoring, especially with chronic disease present.

❓ Frequently Asked Questions

How fast will my dog improve?

Many dogs show reduced limping and improved mobility within 1–2 hours; most reach peak benefit in hours to a few days :contentReference[oaicite:23]{index=23}.

Can my dog take other arthritis medications alongside Galliprant®?

Avoid combining other NSAIDs or steroids. Safe combinations (e.g., joint supplements, certain pain meds) should be discussed with your vet.

Is Galliprant® safe for senior dogs?

Generally yes, but dogs with kidney, liver, or heart disease may need lower starting doses and routine check-ups.

What if signs return between doses?

Speak with your vet—may indicate dose adjustment, missed dose, or need for multi-modal pain therapy.

📌 Final Takeaways

• Galliprant® is a first-in-class EP4 receptor NSAID, offering targeted osteoarthritis pain relief with potentially fewer side effects.
• It’s given **2 mg/kg once daily**, best on an empty stomach; onset within hours.
• Works effectively for chronic joint pain, but may be less potent than COX‑2 NSAIDs in acute severe pain.
• Generally well tolerated—common GI signs are mild; serious reactions are rare. Monitoring is still advised.
• Avoid use in young, pregnant, heart-diseased dogs or in combination with other NSAIDs.
  Routine follow-ups and lab tests help ensure your dog’s safety while relieving pain in 2025 and beyond. 🐾❤️

Thinking of using Galliprant® for your canine companion? Download the Ask A Vet app for dosing reminders, medication tracking, side-effect alerts, and 24/7 veterinary guidance—keeping your pet comfortable and mobile year-round. 🐕‍🦺💊