Sucralfate Use in Pets 2025 🐾 | Vet Guide by Dr Duncan Houston BVSc

Sucralfate is a mucosal protectant used off-label in veterinary medicine to treat ulcers and erosions in the mouth, esophagus, stomach, and upper intestines across species—dogs, cats, horses, ferrets, birds, reptiles, and more :contentReference[oaicite:2]{index=2}.

1. 🛡️ Mechanism of Action

In the acidic environment of the stomach (pH <4), sucralfate forms a viscous paste that binds to ulcerated tissue, acting as a shield against acid, enzymes, and bile. It also stimulates protective mucus, prostaglandins, and growth factors :contentReference[oaicite:3]{index=3}.

2. ✅ Common Uses

• Treatment and prevention of ulcers in the gastrointestinal tract (oral to duodenum) in dogs and cats :contentReference[oaicite:4]{index=4}.
• Esophagitis, acid reflux, or damage from NSAIDs and toxins in dogs and cats :contentReference[oaicite:5]{index=5}.
• Gastric ulcers in horses (including neonates), often alongside omeprazole :contentReference[oaicite:6]{index=6}.
• Protective and healing use in small mammals, birds, and reptiles :contentReference[oaicite:7]{index=7}.

3. 💉 Administration & Dosing

• Formulations: tablets, liquid suspension—crush tablets into slurry if needed :contentReference[oaicite:8]{index=8}.
• Recommended doses:
  • Dogs/Cats: 0.25–1 g per 10 lb every 6–12 hours :contentReference[oaicite:9]{index=9}.
  • Horses: 10–22 mg/kg every 6–8 hours on empty stomach :contentReference[oaicite:10]{index=10}.
  • Exotics: species-specific dosing—consult your vet :contentReference[oaicite:11]{index=11}.
• To maximize effect, administer on an empty stomach—at least 1 hr before or 2 hr after meals or other medications :contentReference[oaicite:12]{index=12}.
• Liquid suspensions should be well shaken before dosing :contentReference[oaicite:13]{index=13}.

4. ⚠️ Side Effects & Precautions

• Constipation is the most common side effect in dogs, cats, and horses :contentReference[oaicite:14]{index=14}.
• Vomiting or diarrhea may occur intermittently :contentReference[oaicite:15]{index=15}.
• Rarely causes hypophosphatemia in horses :contentReference[oaicite:16]{index=16}.
• May slow gastric transit—use with caution in cases of constipation or GI obstruction risk :contentReference[oaicite:17]{index=17}.

5. ⚗️ Drug Interactions

Sucralfate binds to and reduces absorption of many oral drugs. To avoid interactions, separate administration by at least 2 hours for:

• Fluoroquinolones, tetracyclines, digoxin, ketoconazole, corticosteroids, NSAIDs, antacids, phenytoin :contentReference[oaicite:18]{index=18}.

Discuss your pet’s full medication list with your veterinarian :contentReference[oaicite:19]{index=19}.

6. 🩺 Monitoring Guidelines

• Typically, no special monitoring is required :contentReference[oaicite:20]{index=20}.
• If GI signs worsen (e.g., blood in vomit/stool), contact your vet—further diagnostics may be needed :contentReference[oaicite:21]{index=21}.
• Reassess constipation or electrolyte imbalances if ongoing side effects occur :contentReference[oaicite:22]{index=22}.

7. ⏱️ Duration & Compliance Tips

• Treatment often lasts weeks to months—follow your veterinarian’s guidance :contentReference[oaicite:23]{index=23}.
• Consistent timing on empty stomach ensures effectiveness.
• Never double a missed dose—wait until the next scheduled time :contentReference[oaicite:24]{index=24}.
• Store at room temperature, tightly closed, away from moisture and light :contentReference[oaicite:25]{index=25}.

8. 📊 Quick Overview Table

9. 🧡 Final Thoughts

Sucralfate is a safe, effective, and widely-used GI protectant across many species. With proper administration—on an empty stomach—and awareness of drug interactions and mild side effects, it helps your pet’s ulcers heal and prevents further irritation. Always follow your veterinarian's advice and follow up if symptoms persist. 🐶🐱🐴

— Dr Duncan Houston BVSc

👉 Visit AskAVet.com or download the Ask A Vet app for dosing charts, medication schedule support, and expert guidance through your pet’s treatment. 📱✨